tidyvpc - VPC Percentiles and Prediction Intervals
Perform a Visual Predictive Check (VPC), while accounting for stratification, censoring, and prediction correction. Using piping from 'magrittr', the intuitive syntax gives users a flexible and powerful method to generate VPCs using both traditional binning and a new binless approach Jamsen et al. (2018) <doi:10.1002/psp4.12319> with Additive Quantile Regression (AQR) and Locally Estimated Scatterplot Smoothing (LOESS) prediction correction.
Last updated 11 days ago
7.81 score 11 stars 1 dependents 47 scripts 685 downloadsCertara.R - Easily Install Pharmacometric Packages and Shiny Applications Developed by Certara
A convenient set of wrapper functions to install pharmacometric packages and Shiny applications developed by Certara PMX and Integrated Drug Development (iDD). The functions ensure the successful installation of packages from non-standard repositories.
Last updated 5 months ago
pharmacometricsr-pkg
4.45 score 14 stars 2 scripts 329 downloadsCertara.RsNLME - Pharmacometric Modeling
Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling and simulation with powerful tools for Nonlinear Mixed-Effects (NLME) modeling. The package provides access to the same advanced Maximum Likelihood algorithms used by the NLME-Engine in the Phoenix platform. These tools support a range of analyses, from parametric methods to individual and pooled data analysis <https://www.certara.com/app/uploads/2020/06/BR_PhoenixNLME-v4.pdf>. Execution is supported both locally or on remote machines.
Last updated 4 months ago
3.01 score 2 dependents 34 scripts 745 downloadsCertara.VPCResults - Generate Visual Predictive Checks (VPC) Using 'shiny'
Utilize the 'shiny' interface to parameterize a Visual Predictive Check (VPC), including selecting from different binning or binless methods and performing stratification, censoring, and prediction correction. Generate the underlying 'tidyvpc' and 'ggplot2' code directly from the user interface and download R or Rmd scripts to reproduce the VPCs in R.
Last updated 4 months ago
2.11 score 13 scripts 284 downloadsCertara.RsNLME.ModelExecutor - Execute Pharmacometric Models Using 'shiny'
Execute Nonlinear Mixed Effects (NLME) models for pharmacometrics using a 'shiny' interface. Specify engine parameters and select from different run options, including simple estimation, stepwise covariate search, bootstrapping, simulation, visual predictive check, and more. Models are executed using the 'Certara.RsNLME' package.
Last updated 14 days ago
2.00 score 3 scripts 231 downloadsCertara.RDarwin - Interface for 'pyDarwin' Machine Learning Pharmacometric Model Development
Utilities that support the usage of 'pyDarwin' (<https://certara.github.io/pyDarwin/>) for ease of setup and execution of a machine learning based pharmacometric model search with Certara's Non-Linear Mixed Effects (NLME) modeling engine.
Last updated 1 months ago
1.70 score 282 downloadsCertara.RsNLME.ModelBuilder - Pharmacometric Model Building Using 'shiny'
Develop Nonlinear Mixed Effects (NLME) models for pharmacometrics using a 'shiny' interface. The Pharmacometric Modeling Language (PML) code updates in real time given changes to user inputs. Models can be executed using the 'Certara.RsNLME' package. Additional support to generate the underlying 'Certara.RsNLME' code to recreate the corresponding model in R is provided in the user interface.
Last updated 3 months ago
1.70 score 8 scripts 287 downloads