tidyvpc - VPC Percentiles and Prediction Intervals

Perform a Visual Predictive Check (VPC), while accounting for stratification, censoring, and prediction correction. Using piping from 'magrittr', the intuitive syntax gives users a flexible and powerful method to generate VPCs using both traditional binning and a new binless approach Jamsen et al. (2018) <doi:10.1002/psp4.12319> with Additive Quantile Regression (AQR) and Locally Estimated Scatterplot Smoothing (LOESS) prediction correction.

Last updated 2 days ago

8.01 score 11 stars 1 packages 49 scripts 923 downloads

Certara.R - Easily Install Pharmacometric Packages and Shiny Applications Developed by Certara

A convenient set of wrapper functions to install pharmacometric packages and Shiny applications developed by Certara PMX and Integrated Drug Development (iDD). The functions ensure the successful installation of packages from non-standard repositories.

Last updated 11 days ago

pharmacometricsr-pkg

4.75 score 14 stars 2 scripts 314 downloads

vachette - A Method for Visualization of Pharmacometric Models

A method to visualize pharmacometric analyses which are impacted by covariate effects. Variability-aligned covariate harmonized-effects and time-transformation equivalent ('vachette') facilitates intuitive overlays of data and model predictions, allowing for comprehensive comparison without dilution effects. 'vachette' improves upon previous methods Lommerse et al. (2021) <doi:10.1002/psp4.12679>, enabling its application to all pharmacometric models and enhancing Visual Predictive Checks (VPC) by integrating data into cohesive plots that can highlight model misspecification.

Last updated 2 months ago

3.60 score 1 stars 6 scripts 173 downloads

Certara.RsNLME - Pharmacometric Modeling

Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling and simulation with powerful tools for Nonlinear Mixed-Effects (NLME) modeling. The package provides access to the same advanced Maximum Likelihood algorithms used by the NLME-Engine in the Phoenix platform. These tools support a range of analyses, from parametric methods to individual and pooled data analysis <https://www.certara.com/app/uploads/2020/06/BR_PhoenixNLME-v4.pdf>. Execution is supported both locally or on remote machines.

Last updated 3 days ago

2.23 score 34 scripts

Certara.VPCResults - Generate Visual Predictive Checks (VPC) Using 'shiny'

Utilize the 'shiny' interface to parameterize a Visual Predictive Check (VPC), including selecting from different binning or binless methods and performing stratification, censoring, and prediction correction. Generate the underlying 'tidyvpc' and 'ggplot2' code directly from the user interface and download R or Rmd scripts to reproduce the VPCs in R.

Last updated 1 months ago

1.81 score 13 scripts 396 downloads

Certara.NLME8 - Utilities for Certara's Nonlinear Mixed-Effects Modeling Engine

Perform Nonlinear Mixed-Effects (NLME) Modeling using Certara's NLME-Engine. Access the same Maximum Likelihood engines used in the Phoenix platform, including algorithms for parametric methods, individual, and pooled data analysis <https://www.certara.com/app/uploads/2020/06/BR_PhoenixNLME-v4.pdf>. The Quasi-Random Parametric Expectation-Maximization Method (QRPEM) is also supported <https://www.page-meeting.org/default.asp?abstract=2338>. Execution is supported both locally or on remote machines. Remote execution includes support for Linux Sun Grid Engine (SGE), Terascale Open-source Resource and Queue Manager (TORQUE) grids, Linux and Windows multicore, and individual runs.

Last updated 1 months ago

1.70 score 450 downloads